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Dr. Vladimir Tolstikov
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Metabolomics Core Manager
The UC Davis Genome Center
451 Health Sciences Drive
Davis, CA 95616-8816
contact: vtolstikov@ucdavis.edu
Tel. (530) 754-5357 (Office)
(530) 754-8553 (Lab)
Professional Preparation
| 1983 | PhD (Organic Chemistry), All Union Institute of Chemical Means for Plant Protection, Moscow, Russia |
| 1977 | MS (Chemistry), M.V. Lomonosov Institute of Fine Chemical Technology, Moscow, Russia |
Appointments
3/2005 - | Core Manager, Metabolomics Core Facility, UCD Genome Center, UC Davis |
| 8/2004 - 3/2005 | Postdoctoral Associate Virginia Bioinformatics Institute Blacksburg, Virginia, U.S.A. |
| 8/2001 – 8/2004 | Senior Scientist, Metabolite profiling group Max Planck Institute of Molecular Plant Physiology, Golm, Germany. |
| 8/2000 – 8/2001 | Postdoctoral Scientist, Metabolite profiling group Max Planck Institute of Molecular Plant Physiology, Golm, Germany. |
| 5/1999 – 7/2000 | Nucleic Acids Organic Chemist LAROVA Biochemie GmbH, Teltow, Germany. |
| 11/1995 – 5/1999 | Senior Researcher, Laboratory of Structure and Functions of Human Genes Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. |
Recent publications
Book Chapters
- Tolstikov, V.V.: Metabolic Analysis.Methods in Molecular Biology, vol.544: Micro and Nano Technologies in Bioanalysis, 343-353, 2009 (James W. Lee and Robert S. Foote, The Humana Press Inc., Totowa, NJ, USA).
- Tolstikov, V.V., Fiehn, O., Tanaka, N.,: Application of LC-MS analysis in Metabolomics. Methods in Molecular Biology, vol.358: Metabolomics: Methods and Protocols, 141-155, 2007 (Wolfram Weckwerth, The Humana Press Inc., Totowa, NJ, USA)
- Ikegami, T., Kobayashi, H., Kimura, H., Tolstikov, V., Fiehn, O., and Tanaka, N.,: Chapter 8: High-Performance Liquid Chromatography for Metabolomics: High-Efficiency Separations Utilizing Monolithic Silica Columns. Metabolomics. The Frontier of Systems Biology, 107-126, 2005 (Springer-Verlag, Tokyo)
- Tanaka, N., Tolstikov, V., Weckwerth, W., Fiehn, O., Fukusaki, H.,: Micro HPLC for Metabolomics. Frontier of metabolomic research, 85-100, 2003 (Springer-Verlag, Tokyo) (in Japanese)
Conference Abstracts
- Vladimir Tolstikov: Metabolic Biomarkers Discovery Project. Molecular Diagnostics World Congress, South San Francisco, CA, USA, August 6-7, 2009.
- Vladimir Tolstikov: Metabolic Biomarkers Discovery. 57th ASMS Conference, Philadelphia, PA, USA, May 31-June 4, 2009.
- Vladimir Tolstikov: Small Molecule Biomarkers Discovery. Biomarker World Congress 2009, Philadelphia, PA, USA, May 27-29, 2009.
- V.V., Tolstikov: Mass Spectrometry-Derived Metabolic Biomarkers and Signatures in Diagnostic Development. Biomarker Discovery Summit 2008, Philadelphia, PA, September 29 - October 1, 2008.
- Application of Genetic Algorithms in Search for Urinary Biomarkers for Renal Cell Carcinoma. Fourteenth Annual Cancer Research Symposium, UC Davis Cancer Center, Sacramento, September 25-26, 2008.
- V.V., Tolstikov:
- V.V., Tolstikov: Metabolic Biomarkers and Signatures. Translating Proteomics Discoveries into Clinical Diagnostics, AACC, Seattle, WA, USA, May 9-10, 2008.
Articles
- W. Zou, V. Tolstikov: Pattern Recognition and Pathway Analysis with Genetic Algorithms Mass Spectrometry Based Metabolomics: Algorithms, 2009, No 2(2), pp 638–666.
- W. Zou, V. Tolstikov: Probing Genetic Algorithms for Feature Selection in Comprehensive Metabolic Profiling: Rapid Commun. Mass Spectrom., 2008, No 22, pp 1312–1324.
- Tobias Kind, Vladimir Tolstikov, Oliver Fiehn and Robert H. Weis: A comprehensive urinary metabolomic approach for identifying kidney cancer: Analytical Biochemistry, 15 April 2007, Vol. 363, Issue 2, pp 185-195
- V.J., Nikiforova, J., Kopka, V., Tolstikov, O., Fiehn, L., Hopkins, M.J., Hawkesford, H., Hesse, R., Hoefgen: Systems Rebalancing of Metabolism in Response to Sulfur Deprivation, as Revealed by Metabolome Analysis of Arabidopsis Plants: Plant Physiol. 2005, Vol. 138, pp 306-318.
- S. Wienkoop, M. Glinski, N. Tanaka, V. Tolstikov, O. Fiehn and W. Weckwerth: Linking protein fractionation with multidimensional monolithic reversed-phase peptide chromatography/mass spectrometry enhances protein identification from complex mixtures even in the presence of abundant proteins: Rapid Commun. Mass Spectrom., 2004, No 18, pp 643–650.
- V.V., Tolstikov, A., Lommen, K., Nakanishi, N., Tanaka, O., Fiehn:Monolithic silica-based capillary reversed phase liquid chromatography / electrospray mass spectrometry for plant metabolomics: Anal Chem, 2003, v. 75, No 23, pp 6737-6740.
- Tolstikov, V.V., Fiehn, O.: Analysis of Highly Polar Compounds of Plant Origin: Combination of Hydrophilic Interaction Chromatography and Electrospray Ion Trap Mass Spectrometry. Anal Biochem, v. 301, No 2, 298-307, 2002.
